Polymorphs discrimination using Morphologically-Directed Raman Spectroscopy

Several pharmaceutical ingredients (API) tend to crystallize in different crystalline packings (polymorphs). In a pharmaceutical formulation, the identity or the possible conversion of the API polymorph could alter the characteristics and the efficacy of the pharmaceutical form, leading to a different bioavailability. In this work we show how polymorphism can be successfully recognized and characterized by using MDRS (Morphologically-Directed Raman Spectroscopy), a powerful technique that combines automated particle imaging with Raman spectroscopy to provide particle size, shape and chemical identification in a single analysis.