Automatic Image Analysis
Static Automated Image Analysis is the ideal technique to obtain, through high quality images on statistically representative numbers of particles, accurate information about particle shape (circularity, elongation, convexity, etc.), particle size and particle transparency. The reproducibility of the measurements obtained with the instrument installed in Alfatestlab is also guaranteed by an automated particle dispersion system. The technique is validated by the ISO13322-1: 2014.
We can perform automatic measurements on filters to quantify and differentiate the presence of contaminants or oversized particles, useful information for industries such as pharmaceutical, automotive, environmental, etc.
Thank to Morphologically Directed Raman Spectroscopy MDRS integrated in the Morphologi 4ID system Alfatestlab can provide Raman spectra of any particle in order to chemically identify it in a multi-component sample. Ask us more about it!
Scanning Electron Microscopy
Scanning Electron Microscopy (SEM) is used in many areas not strictly related to particles. For particle size and particle shape analysis, the SEM present in Alfatestlab is coupled to an automatic powder dispersion system on the stubs and to a dedicated software called ParticleMetric able to provide automatic reports on particle size distribution and particle shape.
Several pharmaceutical ingredients (API) tend to crystallize in different crystalline packings (polymorphs). In a pharmaceutical formulation, the identity or the possible conversion of the API polymorph could alter the characteristics and the efficacy of the pharmaceutical form, leading to a different bioavailability. In this work we show how polymorphism can be successfully recognized and characterized by using MDRS (Morphologically-Directed Raman Spectroscopy), a powerful technique that combines automated particle imaging with Raman spectroscopy to provide particle size, shape and chemical identification in a single analysis.