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Stability analysis

Liquid dispersions, suspensions and emulsions, are encountered in a wide range of industry including Food & beverage, pharmaceuticals, personal care, paint, ceramics, speciality chemicals…. Stability is a key parameter that will impact processing, performance, appearance, texture, storage condition and shelf life of the final product. To achieve stability, particle size, particle charge and rheology are typical analysis required during the formulation stage of the product. 

The support of an external laboratory will allow you to ensure the conformity of your products before they are released on the market by carrying out stability studies. AlfatestLab offers high level of expertise combined with a wide range of technologies for stability studies, please see here below for detailed information.

Static Multiple Light scattering to offer accelerated aging tests.

SMLS is a consolidated technique for stability analysis allowing to detect and characterize destabilization phenomenon in a concentrated media (sedimentation or creaming layers, aggregates, agglomerates, or coalescence). Being up to 200x faster than conventional shelf life tests SMLS is an ideal tool for screening different formulations and predict which formulation will have longer shelf life hence better stability. The technique provides a unique a stability index that allows to rank samples from the most stable to the least stable based on a single number.

Particle charge (Zeta Potential) measurement by Electrophoretic light scattering

The zeta potential of particles is a key indicator of the stability of a colloidal dispersion. Zeta potential depends on both the nature of the particle surface itself and the composition of the aqueous phase.  To overcome Van der Waals forces attractive forces between particles high zeta potential value (repulsion forces) is required. Any change in the aqueous phase such as pH, concentration of ions, chemistry, and concentration of surfactant in the formulation will have an influence on the zeta potential therefore on stability.

AlfatestLab can provide Zeta potential measurements of your samples and perform pH and concentration titrations to explore a full range of formulations and assess the best conditions for stability.

Particle size analysis by Laser Diffraction & Dynamic Light scattering

Suspensions or emulsions are made of either solid particles or droplets dispersed in a liquid phase. Particle size will directly impact the overall stability as larger particles will settle faster than smaller ones while smaller particles will have higher tendency to aggregate due Van der Waals attraction forces. Controlling particle size distribution is key in both formulation and QC process to achieve product stability.

AlfatestLab offers particle size analysis from 0,3nm up to 3500 microns for suspensions, emulsions, and powders, as well as method development and method transfer.

Viscosity, visco-elastic and flow properties by rotational rheology measurement

Parameters such as concentration, time, temperature, pressure, agitation, stress, particle size, particle shape, Zeta potential can impact final product flow properties, viscosity and therefore stability. Rheology is an essential technique when testing the long-term stability of dispersions (suspension, emulsion or paste). To avoid e.g. sedimentation, viscosity at low shear rates (simulating samples at rest condition) must be high to slow down the sedimentation process. To avoid phase separation at rest conditions, yield stress is a useful property that can be achieved by adding suitable components in the formulation.

Most liquid dispersions show shear thinning behaviour (viscosity decrease at higher shear rate) often ending to product instability upon specific condition such as shipment.  Performing thixotropy test allows to control viscosity profile over time to increase final product stability.

In AlfatestLab our rheology experts are available to set-up dedicated tests to optimise the long-term stability of your products.         

Ask our experts about the technique and how we can provide quick, accurate and objective stability testing.



Alfatestlab services for Home & Personal Care industry

Alfatestlab is equipped with a full range of scientific instruments for the analysis and optimization of cosmetic formulations, and can provide analytical support to your R&D or quality control groups by monitoring a large number of physical parameters of raw materials, intermediate or final formulations.

Alfatestlab services for Food and Drinks industries

In Alfatestlab we support the food industry since several years in formulation, deformulation and bench-marking projects, trouble shooting and R&D by providing material characterization by innovative analytical techniques.

Battery material testing

Porosity, Particle Size and Shape, Packing Density, viscosity: all these characteristics influence the performances and the capacity of the electrodes of a Li-Ion battery, Alfatestlab has the technologies and the competences to support your Li-Ion batteries characterization needs.

CPhI Milano November 9th-11th 2021

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There's always time for a coffee break!

Analysis of coffee particle characteristics, coffee creaming and bulk powder flow properties together with sensory analysis and high resolution SEM images can help you improve your coffee production process.

Zinc Oxide: an additive widely used in different industries

Zinc oxide (ZnO) is an inorganic white powder, insoluble in water and used as an additive in numerous materials and products. Characterization of Zinc oxide powder and particles properties is fundamental to improve final product quality.

Hydroxyapatite (HAp) for a wide range of applications in the biomedical field

The synthetic and natural HA differ in terms of physical microstructure, crystal size, and porosity, but chemical similarities to bone, in both forms, as well as biocompatibility, bioactivity and thermal stability in the body fluid pose Hydroxyapatite (HAp)  as an attractive material for a wide range of applications in the biomedical field. Find out more!

Pharmaceutical Excipients

Physical properties of excipients influence the stability, bioavailability, and processability of the dosage forms. Alfatestlab is equipped with all the analytical techniques necessary to support you in choosing the right excipient for your formulation: particle size, particle shape, flowability, density, surface area and much more!

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